The rate of birth defects did not differ between the women who received antivirals 1, pregnancies with 40 birth defects; 2. These results did not change when the analysis was restricted to acyclovir. Risk estimates were similar for acyclovir and valacyclovir; however, the authors caution that there were relatively few exposures reported for valacyclovir and famciclovir.
Conclusion: Use of acyclovir in the first trimester does not increase birth defects, and it should be the antiviral drug of choice in early pregnancy.
Already a member or subscriber? Log in. Interested in AAFP membership? Learn more. Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. August 25, ; 8 — This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.
Contact afpserv aafp. However, this medicine is more effective if you begin using it when the first outbreak happens. Acyclovir is considered a safe medicine and can be used during pregnancy, too.
However, it should only be used after being prescribed by your registered medical practitioner. This category B drug has no proven side-effects. But, if acyclovir is taken during the first trimester of pregnancy, it may cause complications in the pregnancy or may lead to congenital disabilities in your baby.
Therefore, in most cases, your doctor may prescribe this medicine only in the later stages of pregnancy. The dosage of acyclovir during pregnancy mainly depends on the severity of your condition.
You may be prescribed mg that should be taken 4 to 5 times a day or mg taken 3 times a day, depending on your condition. You may have to take medicine for a week to 10 days or longer in some cases. The regular usage of the medicine may not only ensure the reduction in the outbreaks, but it may also prevent the infection from getting passed on to your baby.
Acyclovir is a safe drug; however, it may sometimes cause some mild to severe side-effects in people. We shall be discussing both the side-effects separately in the following section. If any of these side effects are observed after taking this medicine, you must report the same to your doctor immediately. Exercising some of the following precautions may be helpful in reducing the side effects of the medicine:. If any kind of medicine with potential side effects is consumed during this time, it may cause congenital disabilities in babies.
However, there is no scientific evidence available that states any probable birth defects in babies after mothers have been prescribed acyclovir in the second or third trimester of pregnancy.
Brain development of a baby happens in the later stages of the pregnancy, too. Hence, mothers are worried if the consumption of this medicine would cause a problem in their babies or not. Herpes zoster. Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review. J Infect Dis. Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States.
Recurrence rates in genital herpes after symptomatic first-episode infection. Ann Intern Med. The acquisition of herpes simplex virus during pregnancy. N Engl J Med. A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction. Mayo Clin Proc. Valacyclovir for herpes simplex virus infection: long-term safety and sustained efficacy after 20 years' experience with acyclovir.
Safety of famciclovir in patients with herpes zoster and genital herpes. Antimicrob Agents Chemother. Medications in pregnancy and lactation: part 1 teratology. Obstet Gynecol. Preclinical toxicology studies with acyclovir: teratologic, reproductive and neonatal tests.
Fundam Appl Toxicol. Gross-structural defects in rats after acyclovir application on day 10 of gestation. Arch Toxicol. US Food and Drug Administration. Zovirax acyclovir product information , GlaxoSmithKline, Accessed July 5, Valtrex valacyclovir product information , GlaxoSmithKline, Famvir famciclovir product information , Novartis, Pregnancy outcomes following systemic prenatal acyclovir exposure: conclusions from the international acyclovir pregnancy registry, Ratanajamit C, Vinther Skriver M, et al.
Adverse pregnancy outcome in women exposed to acyclovir during pregnancy: a population-based observational study. Scand J Infect Dis. The outcomes of pregnancy in women exposed to newly marketed drugs in general practice in England.
Br J Obstet Gynaecol. Knudsen LB, Olsen J. The Danish Medical Birth Registry. Dan Med Bull. Ultrasonography of pregnant women in Denmark description of the development since Ugeskr Laeger.
Validation of the Danish Birth Registration. J Clin Epidemiol. Danmarks Statistik. Accessed August 2, The Danish National Hospital Register: a valuable source of data for modern health sciences.
Eurocat Network. Chapter 3. Accessed March 3, The Danish Civil Registration System: a cohort of eight million persons. Predictive value and completeness of the registration of congenital abnormalities in three Danish population-based registries.
Scand J Public Health. Validity of diagnoses of cardiac malformations in a Danish population-based hospital-discharge registry. Int J Risk Saf Med. Acyclovir Exposure and Birth Defects. Save Preferences.
Privacy Policy Terms of Use. This Issue. Citations View Metrics. Twitter Facebook More LinkedIn. Original Contribution. Study Cohort. Antiviral Drug Exposure. Birth Defects. Potential Confounders. Statistical Analysis. Back to top Article Information. Financial Disclosures: None reported. Access your subscriptions. Access through your institution. Add or change institution. Free access to newly published articles. Purchase access. Rent article Rent this article from DeepDyve.
0コメント