In , around 3 million patients in the United States used this medication, and according to a study , there is a risk for drug-drug interactions to occur when patients using this medication are taking it out of the hospital.
Moreover, the severity of interactions depends on the type of drug it interacts with. Some interactions can lead to fatal side effects like heart disease, while others only enhance drowsiness. In this article, information about Hydroxyzine interactions such as mixing it with alcohol, weed, interaction of Hydroxyzine and Benadryl, stimulants, antidepressants, opioids, sedatives, benzodiazepines, and NSAIDS, and how to avoid dangerous drug interactions will be provided.
Hydroxyzine interactions with alcohol is considered a food-drug interaction. According to a study , Vistaril is not a depressant, and its use leads to sedative effects due to the suppression activity of the drug in the central nervous system. Alcohol, on the other hand, is a depressant. So, taking it with alcohol produces a moderate to high drug interaction in the body. When taken together, Vistaril and Alcohol could serve as CNS depressants and, thus, through the concomitant use, will produce a variety of undesired effects especially during pregnancy.
In another study , alcohol enhances the effects of Vistaril on the central nervous system which leads to severe drowsiness, impaired cognitive function, loss of consciousness, decreased motor skills, and respiratory depression. In the same study, this interaction is more pronounced in elderly people with health conditions. This type of interaction is considered as drug-drug interaction and synergism.
According to a study , weed has sedative effects like that of Vistaril. For this reason, it can be said that the interaction of Hydroxyzine and weed is more likely the same as the interaction of alcohol and Vistaril. Taking it and weed together is dangerous not only to the health but also to life. When these two are taken together, severe drowsiness may occur which can lead to accidents including fatal road mishaps when a person using it is operating machinery.
Additionally, mixing them together reduces the alertness and clear vision of a person, increased fatigue, and severe sedation. One use of Vistaril is an antihistamine and it works by suppressing the histamines in the body. It must be stressed, though, that Hydroxyzine interactions with other antihistamines can cause more problems than they solve if they are consumed without the instructions of a medical doctor.
Moreover, it is possible to take two different antihistamines together but only a medical doctor can tell what antihistamine medications can be combined, what are the proper dosage strengths, and the frequency. According to a study , mixing Vistaril with other antihistamines may cause overdose and symptoms such as increased daytime somnolence, increased drowsiness, and blurred vision. In the same study, topical antihistamines, such as Diphenhydramine cream, ointment, and spray , can also cause drug interactions which lead to increased antihistamine effects.
One of the most frequent inquiries is whether Hydroxyzine and Benadryl can be mixed. Although allergic reactions rarely occur when taking Vistaril, combining it with another antihistamine is dangerous to the health and one example of this is Benadryl. Hydroxyzine and Benadryl are FDA-approved antihistamines but for the former prescription is needed.
Combining them together produces a moderate drug interaction. This means that the combination is undesirable due to the side effects it provokes. Side effects of the interaction of these drugs include worsening symptoms of drowsiness, problems with urinating, cognitive problems like memory loss, blurred vision, dry mouth, heat intolerance, flushing, irregular heartbeat, abdominal cramping, and constipation.
According to a study , taking Hydroxyzine and Benadryl together causes cardiac toxicity since there is an increased risk of QT prolongation delay in the beating of the heart and torsades de pointes life-threatening heart rhythm disturbances to occur. Vistaril is considered a downer depressants or tranquilizing drugs , while stimulants are uppers increase energy and alertness.
At the same time, the outcome of interaction depends on the potency of the drugs used, as well as the time Vistaril stays in the system. Moreover, the interaction between these drugs is considered as drug-drug interactions with antagonistic effects, meaning, one drug may block the effect of the other drug.
In this section, information about the interaction of this drug with Adderall and caffeine will be provided. Most of the interactions are based on the dose of the medication. In this case, Vistaril is a potent downer that has the ability to lessen stimulatory activity of stimulants such as Adderall. In one study , it was reported that antihistamines like Hydroxyzine affect what the body does to the stimulant.
Moreover, the side effects of taking Hydroxyzine and Adderall cause certain dangers to the health such as changes in the blood pressure of a patient which can lead to irregular heart rhythms and stroke. When taking Vistaril or any other medications, it is important to understand that diet is a great factor in optimizing the effectiveness of the medications being taken.
Hydroxyzine and caffeine interaction is considered as food-drug interaction. Vistaril increases sedation while Caffeine decreases sedation. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases.
If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:. Take this medicine only as directed by your doctor.
Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Shake the oral liquid well before using. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. The dose of this medicine will be different for different patients.
Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Keep from freezing. It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. Make sure your doctor knows if you are pregnant.
Symptoms of overdose include severe drowsiness, dry mouth, difficulty urinating, headache, rapid heartbeat, confusion, impaired coordination, slow reflexes, seizures, or coma. To date, there are no known problems associated with the long-term use of hydroxyzine. It is a safe and effective medication when used as directed.
Last Updated: January This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists.
This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions.
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